Scientists Find Key For T Cells To Fight Cancer & Infections

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Researchers at The Wistar Institute have found multiple receptors on the outside of the body's killer immune system cells which they believe can be selectively targeted to keep the cells in superb infection- and disease-fighting condition.

The researches said in a study published online November 30 in Nature Immunology that they've discovered seven different receptors on T cells that can tamp down immune responses during a prolonged battle with an infectious pathogen or against developing cancer.

 
"We are starting to see a picture emerging of a really tuneable array of inhibitory receptors expressed on T cells" study's lead author Wherry says. "That suggests it may be possible to not only dramatically enhance antiviral or antitumor T cell responses, but also to fine tune which response you want to enhance in order to reverse T cell exhaustion and continue fighting an infection or disease. "

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